Boost Your Digestive Enzymes

Plagued by stomach upset? Digestive enzymes like protease, amylase, and lipase could soothe your system. Find out the scientific verdict and where to get them.
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We’ll Try To Make This Easy To Digest

Do you have a digestion-related problem?

If so, you’re far from alone; around 40% of Americans have digestive problems serious enough to disrupt everyday life:

New survey finds forty percent of Americans’ daily lives are disrupted by digestive troubles

…which puts Americans just a little over the global average of 35%:

Global Burden of Digestive Diseases: A Systematic Analysis of the Global Burden of Diseases Study, 1990 to 2019

Mostly likely on account of the Standard American Diet, or “SAD” as it often gets abbreviated in scientific literature.

There’s plenty we can do to improve gut health, for example:

Today we’re going to be examining digestive enzyme supplements!

What are digestive enzymes?

Digestive enzymes are enzymes that break down food into stuff we can use. Important amongst them are:

  • Protease: breaks down proteins (into amino acids)
  • Amylase: breaks down starches (into sugars)
  • Lipase: breaks down fats (into fatty acids)

All three are available as popular supplements to aid digestion. How does the science stack up for them?

Protease

For this, we only found animal studies like this one, but the results have been promising:

Exogenous protease supplementation to the diet enhances growth performance, improves nitrogen utilization, and reduces stress

Amylase

Again, the studies for this alone (not combined with other enzymes) have been solely from animal agriculture; here’s an example:

The Effect of Exogenous Amylase Supplementation on the Nutritional Value of Peas

Lipase

Unlike for protease and amylase, now we have human studies as well, and here’s what they had to say:

❝Lipase supplementation significantly reduced stomach fullness without change of EGG.

Furthermore, lipase supplementation may be helpful in control of FD symptom such as postprandial symptoms❞

~ Dr. Seon-Young Park & Dr. Jong-Sun Rew

Read more: Is Lipase Supplementation before a High Fat Meal Helpful to Patients with Functional Dyspepsia?

(short answer: yes, it is)

More studies found the same, such as:

Lipase Supplementation before a High-Fat Meal Reduces Perceptions of Fullness in Healthy Subjects

All together now!

When we look at studies for combination supplementation of digestive enzymes, more has been done, and/but it’s (as you might expect) less specific.

The following paper gives a good rundown:

Pancrelipase Therapy: A Combination Of Protease, Amylase, & Lipase

Is it safe?

For most people it is quite safe, but if taking high doses for a long time it can cause problems, and also there may be complications if you have diabetes, are otherwise immunocompromised, or have some other conditions (listed towards the end of the above-linked paper, along with further information that we can’t fit in here).

As ever, check with your doctor/pharmacist if you’re not completely sure!

Want some?

We don’t sell them, but for your convenience, here’s an example product on Amazon that contains all three 😎

Enjoy!

We’ll Try To Make This Easy To Digest

Do you have a digestion-related problem?

If so, you’re far from alone; around 40% of Americans have digestive problems serious enough to disrupt everyday life:

New survey finds forty percent of Americans’ daily lives are disrupted by digestive troubles

…which puts Americans just a little over the global average of 35%:

Global Burden of Digestive Diseases: A Systematic Analysis of the Global Burden of Diseases Study, 1990 to 2019

Mostly likely on account of the Standard American Diet, or “SAD” as it often gets abbreviated in scientific literature.

There’s plenty we can do to improve gut health, for example:

Today we’re going to be examining digestive enzyme supplements!

What are digestive enzymes?

Digestive enzymes are enzymes that break down food into stuff we can use. Important amongst them are:

  • Protease: breaks down proteins (into amino acids)
  • Amylase: breaks down starches (into sugars)
  • Lipase: breaks down fats (into fatty acids)

All three are available as popular supplements to aid digestion. How does the science stack up for them?

Protease

For this, we only found animal studies like this one, but the results have been promising:

Exogenous protease supplementation to the diet enhances growth performance, improves nitrogen utilization, and reduces stress

Amylase

Again, the studies for this alone (not combined with other enzymes) have been solely from animal agriculture; here’s an example:

The Effect of Exogenous Amylase Supplementation on the Nutritional Value of Peas

Lipase

Unlike for protease and amylase, now we have human studies as well, and here’s what they had to say:

❝Lipase supplementation significantly reduced stomach fullness without change of EGG.

Furthermore, lipase supplementation may be helpful in control of FD symptom such as postprandial symptoms❞

~ Dr. Seon-Young Park & Dr. Jong-Sun Rew

Read more: Is Lipase Supplementation before a High Fat Meal Helpful to Patients with Functional Dyspepsia?

(short answer: yes, it is)

More studies found the same, such as:

Lipase Supplementation before a High-Fat Meal Reduces Perceptions of Fullness in Healthy Subjects

All together now!

When we look at studies for combination supplementation of digestive enzymes, more has been done, and/but it’s (as you might expect) less specific.

The following paper gives a good rundown:

Pancrelipase Therapy: A Combination Of Protease, Amylase, & Lipase

Is it safe?

For most people it is quite safe, but if taking high doses for a long time it can cause problems, and also there may be complications if you have diabetes, are otherwise immunocompromised, or have some other conditions (listed towards the end of the above-linked paper, along with further information that we can’t fit in here).

As ever, check with your doctor/pharmacist if you’re not completely sure!

Want some?

We don’t sell them, but for your convenience, here’s an example product on Amazon that contains all three 😎

Enjoy!

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  • Stop Cancer 20 Years Ago

    Dr. Jenn Simmons shares vital tips on preventing cancer and inflammation, advocating for lifestyle changes and proactive health management at any age.

    Get Abreast And Keep Abreast

    This is Dr. Jenn Simmons. Her specialization is integrative oncology, as she—then a breast cancer surgeon—got breast cancer, decided the system wasn’t nearly as good from the patients’ side of things as from the doctors’ side, and took to educate herself, and now others, on how things can be better.

    What does she want us to know?

    Start now

    If you have breast cancer, the best time to start adjusting your lifestyle might be 20 years ago, but the second-best time is now. We realize our readers with breast cancer (or a history thereof) probably have indeed started already—all strength to you.

    What this means for those of us without breast cancer (or a history therof) is: start now

    Even if you don’t have a genetic risk factor, even if there’s no history of it in your family, there’s just no reason not to start now.

    Start what, you ask? Taking away its roots. And how?

    Inflammation as the root of cancer

    To oversimplify: cancer occurs because an accidentally immortal cell replicates and replicates and replicates and takes any nearby resources to keep on going. While science doesn’t know all the details of how this happens, it is a factor of genetic mutation (itself a normal process, without which evolution would be impossible), something which in turn is accelerated by damage to the DNA. The damage to the DNA? That occurs (often as not) as a result of cellular oxidation. Cellular oxidation is far from the only genotoxic thing out there, and a lot of non-food “this thing causes cancer” warnings are usually about other kinds of genotoxicity. But cellular oxidation is a big one, and it’s one that we can fight vigorously with our lifestyle.

    Because cellular oxidation and inflammation go hand-in-hand, reducing one tends to reduce the other. That’s why so often you’ll see in our Research Review Monday features, a line that goes something like:

    “and now for those things that usually come together: antioxidant, anti-inflammatory, anticancer, and anti-aging”

    So, fight inflammation now, and have a reduced risk of a lot of other woes later.

    See: How to Prevent (or Reduce) Inflammation

    Don’t settle for “normal”

    People are told, correctly but not always helpfully, such things as:

    • It’s normal to have less energy at your age
    • It’s normal to have a weaker immune system at your age
    • It’s normal to be at a higher risk of diabetes, heart disease, etc

    …and many more. And these things are true! But that doesn’t mean we have to settle for them.

    We can be all the way over on the healthy end of the distribution curve. We can do that!

    (so can everyone else, given sufficient opportunity and resources, because health is not a zero-sum game)

    If we’re going to get a cancer diagnosis, then our 60s are the decade where we’re most likely to get it. Earlier than that and the risk is extant but lower; later than that and technically the risk increases, but we probably got it already in our 60s.

    So, if we be younger than 60, then now’s a good time to prepare to hit the ground running when we get there. And if we missed that chance, then again, the second-best time is now:

    See: Focusing On Health In Our Sixties

    Fast to live

    Of course, anything can happen to anyone at any age (alas), but this is about the benefits of living a fasting lifestyle—that is to say, not just fasting for a 4-week health kick or something, but making it one’s “new normal” and just continuing it for life.

    This doesn’t mean “never eat”, of course, but it does mean “practice intermittent fasting, if you can”—something that Dr. Simmons strongly advocates.

    See: Intermittent Fasting: We Sort The Science From The Hype

    While this calls back to the previous “fight inflammation”, it deserves its own mention here as a very specific way of fighting it.

    It’s never too late

    All of the advices that go before a cancer diagnosis, continue to stand afterwards too. There is no point of “well, I already have cancer, so what’s the harm in…?”

    The harm in it after a diagnosis will be the same as the harm before. When it comes to lifestyle, preventing a cancer and preventing it from spreading are very much the same thing, which is also the same as shrinking it. Basically, if it’s anticancer, it’s anticancer, no matter whether it’s before, during, or after.

    Dr. Simmons has seen too many patients get a diagnosis, and place their lives squarely in the hands of doctors, when doctors can only do so much.

    Instead, Dr. Simmons recommends taking charge of your health as best you are able, today and onwards, no matter what. And that means two things:

    1. Knowing stuff
    2. Doing stuff

    So it becomes our responsibility (and our lifeline) to educate ourselves, and take action accordingly.

    Want to know more?

    We recently reviewed her book, and heartily recommend it:

    The Smart Woman’s Guide to Breast Cancer – by Dr. Jenn Simmons

    Enjoy!